In Vitro Antimicrobial Activity of Thiophene Derivative Pitc-2 of Pluchea Indica and Its Mechanism of Action
نویسندگان
چکیده
Extracts of various parts of plants have been used traditionally as component medicines for many years by several communities throughout India. With this background the plant Pluchea indica was selected and a pure compound was extracted from the roots of the plant with the help of methanol following an elaborate procedure. Purity of the compound was confirmed by NMR and was labeled as PITC-2. Antimicrobial action of this specific agent was determined by agar dilution technique with the help of standard international methods; the action was compared with the penicillin and streptomycin. PITC-2 was found to inhibit the action of DNA polymerase which was confirmed by agarose gel electrophoresis.
منابع مشابه
Isolation, Characterization and Sub-acute Toxicity Studies of a New Compound PITC-2 Isolated from Tissue-Cultured Medicinal Plant, Pluchea indica (L.) Less
The present study focused on the chemical characterization of PITC-2 (2-(prop-1-ynyl)-5(5,6-dihydroxyhexa-1, 3-diynyl)-thiophene, a thiophen derivative) isolated from the root extract of tissue-cultured medicinal plant Pluchea indica (L.) Less. Evaluation of sub-acute toxicity study of the new compound was also done in vivo. Methanolic root extract of tissue-cultured P. indica was separated by ...
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